Antimicrobial Lock Solutions in the Prevention of Catheter-Related Bloodstream Infections in Patients Receiving Hemodialysis

Antimicrobial lock solutions in the prevention of catheter-related bloodstream infections in patients receiving hemodialysis.

To the Editor—There is increasing evidence that antimicrobial locks applied within the catheter lumen are effective at preventing catheter-related bloodstream infection (CRBSI), a source of substantial morbidity and mortality in patients receiving hemodialysis (HD). Therefore, we read with interest the recently published review article by John Boyce that, in addition to providing a comprehensiv...

Prevention of Catheter-Related Bloodstream Infections in Patients on Hemodialysis

Fourteen percent of deaths among patients with endstage kidney disease (ESKD) are due to infections, preceded only by cardiovascular diseases (USRDS,2006). According to The United States Renal Data System (USRDS), the number of patients receiving hemodialysis in the United States of America (USA) was 328,000 in 2006(USRDS,2008). Secondary to multiple defects in the ability to kill bacteria, inf...

Prevention of hemodialysis catheter-related bloodstream infection using an antimicrobial lock.

Among currently available vascular access options for hemodialysis, central venous catheters show the poorest reliability, with frequent complications of thrombosis and stenosis impairing patency. The most serious problem, however, is catheter-related bloodstream infection (CRBI), which is typically a cause for removal of the catheter and protracted systemic antibiotic therapy. In our experienc...

Prevention of catheter-related bloodstream infections in patients on hemodialysis: challenges and management strategies.

Catheter-related bloodstream infections are a significant source of morbidity and mortality in the end-stage renal disease population. Although alternative accesses to undergoing renal replacement therapy exist, many patients begin hemodialysis with a dialysis catheter due to logistic and physiologic factors involved in arteriovenous fistula creation and maturation. Colonization of catheters vi...

Ethanol lock therapy in the treatment and prevention of catheter-related bloodstream infections